Drotaverine (Drotaverine) is a drug with antispasmodic, myotropic, vasodilating, hypotensive effects, prescribed to relieve, reduce tone or relieve spasms of smooth muscles of internal organs of various origins. Before use, please read the instructions for use. Next, we’ll look at what Drotaverine injections help with, how to use ampoules correctly, and what is a contraindication.
Composition and release form
The drug is produced in the form of tablets, film-coated tablets and solution for injection.
- Drotaverine tablets are round, beveled and scored, yellow-green in color. Each tablet contains 40 mg of active ingredient. Excipients: povidone (polyvinylpyrrolidone), potato starch, milk sugar, talc and magnesium stearate. 10 pieces in a blister, 1, 2, 3, 4 and 5 blisters in a cardboard box or 100 pieces in a polymer jar and cardboard box.
- Drotaverine Forte tablets contain 80 mg of active ingredient. 10 pieces in a blister, 2 blisters in a cardboard box.
- Injection. 1 ml of solution contains 20 mg of drotaverine hydrochloride. In ampoules of 2 ml, 5 ampoules in blister packs, 2 packs in a cardboard box.
Clinical and pharmacological group: myotropic antispasmodic.
Briefly about cholecystitis
Cholecystitis is an inflammation of the gallbladder, accompanied by a violation of the outflow of bile. Congestion in the gallbladder provokes severe pain and increases the risk of developing secondary bacterial inflammation. Often the disease occurs simultaneously with cholangitis, an inflammation of the bile ducts.
The main symptom of the pathology is acute pain in the right hypochondrium. Usually the pain goes away on its own or after taking a painkiller. But as the inflammatory process develops, the pain becomes stronger each time, occurs regularly, and may be accompanied by nausea, vomiting, and diarrhea.
No-spa is a myotropic antispasmodic, the main active ingredient of which is drotaverine. Available in the form of tablets (in dosages of 40 mg and 80 mg) and solutions for injection.
Cholecystitis is an inflammation of the gallbladder, accompanied by a violation of the outflow of bile. Congestion in the gallbladder provokes severe pain and increases the risk of developing secondary bacterial inflammation. Often the disease occurs simultaneously with cholangitis, an inflammation of the bile ducts.
Abdominal pain is the main symptom of cholecystitis
No-spa is a myotropic antispasmodic, the main active ingredient of which is drotaverine. Available in the form of tablets (in dosages of 40 mg and 80 mg) and solutions for injection.
Pharmacodynamics
Antispasmodic, vasodilator, hypotensive agent. Antispasmodic myotropic action, the mechanism of which is due to a decrease in the flow of calcium into smooth muscle cells as a result of inhibition of phosphodiesterase and intracellular accumulation of cAMP.
Pronouncedly and for a long time expands the smooth muscles of internal organs and blood vessels, reduces their motor activity, lowers blood pressure, and increases cardiac output. In terms of chemical structure and pharmacological properties, it is close to papaverine, but surpasses it in efficiency and duration of action.
When you can't do without doctors
Mild forms of cholecystitis are accompanied by moderate pain and do not always require drug treatment. In this case, to eliminate colic, it is enough to take 1-2 tablets of No-shpa, and the inflammation will go away if you follow a diet (it is recommended to completely exclude fried, fatty, spicy, smoked foods and sweets from the menu, and give up alcohol).
No-shpa injection will help quickly eliminate acute pain
However, a strong inflammatory process can provoke an acute attack of cholecystitis (can occur both with primary inflammation of the gallbladder and with the chronic form of the disease).
During an attack the following are noted:
- severe weakness;
- jaundice (yellowish discoloration of the skin);
- nausea (often with vomiting, which does not bring relief);
- bitter taste in the mouth;
- increased body temperature (up to 37-39 ºС);
- severe paroxysmal or throbbing pain in the area of the right lower rib, navel or epigastrium (sometimes radiating to the back).
In case of an acute attack, the first thing you need to do is call an ambulance. High fever, vomiting and severe pain may indicate acute bile obstruction and the development of peritonitis, which requires urgent surgical intervention.
To alleviate the condition before doctors arrive, you must:
- apply cold to the stomach;
- drink cool still water or mint tea (to relieve nausea);
- take No-shpa or another antispasmodic (for example, Papaverine).
No-spa is an effective and safe drug that quickly eliminates antispasmodic pain in cholecystitis. When taking tablets, the effect of the drug is observed within 10-15 minutes, when administered intramuscularly – within 5 minutes.
What does Drotaverine help with?
In everyday practice, using drugs from a home medicine cabinet, drotaverine tablets help with toothache, headaches, and migraines. In women, drotaverine tablets effectively relieve pain during menstruation and spasms of the smooth muscles of the uterus.
There are other indications for the use of drotaverine. Among them it is worth noting:
- biliary spasms and bile stagnation;
- cholelithiasis;
- spastic colitis;
- stomach ulcer;
- duodenal ulcer;
- attack of renal colic;
- pancreatitis;
- threat of premature birth;
- threat of miscarriage in the second trimester;
- convulsive syndromes.
Drotaverine finds its application in the complex therapy of spastic coronary diseases. For angina pectoris, the effect of drotaverine is weak.
When is Drotaverine prescribed in ampoules?
What are Drotaverine injections prescribed for? Indications for use are:
- spasms of smooth muscles associated with diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;
- spasms of smooth muscles of the urinary tract: nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus;
- for gynecological diseases: dysmenorrhea.
