Comparison of the effectiveness of Ranitidine and De-nol
De-nol is more effective than Ranitidine - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of De-nol is more pronounced, then with Ranitidine it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of therapeutic action; De-Nol and Ranitidine are also different, as is bioavailability - the amount of a drug substance reaching the site of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Why is Ranitidine prescribed for inflammation of the pancreas?
During an acute attack of pancreatitis, when the patient does not eat for 2-3 days, the production of secretion by the pancreas continues. The digestive system works along the chain:
- the stomach produces hydrochloric acid to break down food;
- the pancreas secretes juice containing enzymes;
- in the duodenum, under the influence of pancreatic juice, more complete absorption of food elements occurs.
Treatment is aimed at reducing the production of hydrochloric acid. Groups of drugs used for pancreatitis reduce the secretory activity of the stomach, thereby slowing down the production of enzymes in the pancreas. Due to blockage of the ducts, their outflow is insufficient, so self-digestion of the organ occurs.
Ranitidine is an effective remedy against various types of pancreatitis:
- biliary – the ducts in the gallbladder are blocked, and this causes inflammation of the pancreas;
- alcoholic – swelling of the parenchyma under the influence of alcohol breakdown products;
- destructive pancreatitis – stagnation of pancreatic juice, in which the destruction of pancreatic cells occurs;
- medicinal – the influence of toxic substances after long-term use of medications.
Treatment of the pancreas stops the destructive effect of enzymes, which is very important during exacerbation of chronic pancreatitis and its sluggish chronic form. On the first day after hospitalization of the patient, intramuscular injections are used. The drug penetrates the tissue in a few seconds, and in case of inflammation of the pancreas, the therapeutic effect appears immediately.
Comparison of the safety of Ranitidine and De-nol
The safety of a drug includes many factors.
At the same time, in Ranitidine it is quite similar to De-nol. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Ranitidine, as well as De-nol, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Ranitidine does not have any risks when used, just like De-nol.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of the use of Ranitidine and De-nol.
Ranitidine or Omez: which is better, can it be taken at the same time?
For diseases of the digestive tract, various drugs are prescribed as part of complex treatment. A gastroenterologist sometimes has to choose which is better: Ranitidine or Omez in an individual case.
Ranitidine
Antiulcer agent based on ranitidine hydrochloride. One tablet contains 0.15 or 0.3 g of active substance. Contains lactose monohydrate. One blister contains ten tablets.
Medicinal properties
Ranitidine acts by inhibiting histamine receptors in the cells of the gastric mucosa. Reduces the secretion of hydrochloric acid, reduces the volume of gastric juice, increased under the influence of any factors, including external ones: medications, caffeine, unhealthy diet.
It is characterized by a long-lasting effect and does not affect normal intestinal motility or the liver enzyme system. Peak levels in the blood are observed two to three hours after ingestion. It is excreted within 24 hours by the urinary system and metabolized by the hepatobiliary system.
Indications
Ranitidine is indicated for the following diseases and conditions:
- ulcerative-erosive lesions of the mucous membranes of the gastrointestinal tract against the background of increased acidity;
- ulcers and erosions not associated with Helicobacter;
- diseases of the digestive tract during long-term treatment with non-hormonal painkillers;
- chronic form of gastritis;
- digestive disorders of functional origin;
- reflux esophagitis - as symptomatic therapy.
Contraindications
The use of Ranitidine is prohibited if there is an individual intolerance to its components. It is not prescribed for malignant neoplasms in the stomach, therefore a gastroduodenoscopy is first required to exclude the presence of cancer.
Prohibited for liver cirrhosis, encephalopathy, severe renal failure. Do not take if pregnant or breastfeeding.
Adverse reactions
When treated with the drug, the following undesirable effects are observed:
- blood: abnormal blood count, reversible anemia;
- immunity: allergic reactions, bronchospasm, erythema, urticaria, angioedema;
- CNS: depressive states, reversible confusion, high fatigue, headaches;
- heart: cardiac arrhythmia, chest pain, decreased blood pressure;
- Gastrointestinal tract: dry mouth, nausea, upset stool, poor appetite.
Detection of any adverse reactions requires stopping use and contacting your doctor.
Omez
A medicine based on omeprazole, the concentration of which in the capsule can be 20 and 40 mg. Contains lactose, dispensed ten capsules in a blister.
Contraindications and side effects
Use is prohibited if you are allergic to substituted benzimidazoles and in combination with nelfinavir. Do not take in the first trimester of pregnancy. The most common adverse reactions:
- headaches, pain in the epigastric region;
- bowel dysfunction, nausea;
- reversible change in blood formula;
- increased levels of liver transaminases;
- skin rash, dermatitis, erythema in the presence of allergic reactions.
Drug differences
The difference between Omez and Ranitidine is how they act on the acidity of the stomach, although the end result is the same - a decrease in acidity. Ranitidine inhibits histamine receptors, and Omez inhibits enzymes that carry protons to the site of hydrochloric acid synthesis. Taking into account this feature, the doctor can choose one or another drug.
The differences lie in the active ingredients and their concentrations. However, due to similar effects on the gastrointestinal tract, minimal differences in adverse effects are observed.
Omez also has fewer contraindications, and is allowed for children from one year old and pregnant women from the second trimester under medical supervision. Ranitidine is contraindicated in children under twelve years of age and pregnant women. They also differ in price - Omez is somewhat more expensive, judging by the reviews.
Concomitant use
This condition is not normal - the protective functions of the stomach and intestines are reduced, and the risk of infection of the gastrointestinal tract increases. Therefore, if it is necessary to reduce acidity as part of monotherapy or complex treatment, one of the drugs is chosen. In the absence of a therapeutic effect, they successfully replace each other, thus being analogues in action.
Source: https://GastrituNet.online/lekarstva/h2b/rntd/ranitidin-ili-omez-chto-luchshe.html
Comparison of addiction between Ranitidine and De-nol
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” for Ranitidine is less than the similar values for De-nol. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible.
Brief information about Ranitidine
Just like its analogue, Ranitidine is an antiulcer drug that, by acting on histamine receptors, reduces the secretion of hydrochloric acid. Under the influence of the drug, not only the volume of secretion decreases, but also the concentration of pepsin, which creates good conditions for the healing of ulcers.
Indications for use of the drug are:
- phase of exacerbation of peptic ulcer of the stomach and duodenum;
- prevention of exacerbation of peptic ulcer;
- ulcers caused by stress or medication;
- inflammation of the esophagus, both due to inflammation of the mucous membrane and due to the entry of stomach contents into the esophagus;
- a one-time dose before surgery to prevent aspiration of gastric juice.
The drug should not be taken by children, pregnant and lactating women, as well as patients with kidney disease (may be prescribed with caution).
Ranitin has established itself as a medicine that rarely causes any side effects. Not too often, but body reactions such as headache, fatigue, and skin rashes occur.
Side effects may occur in seriously ill patients while taking other medications and general weakness of the body. In these cases, confusion and hallucinations may occur. Unreasonable long-term use of large doses of the drug causes problems with hormonal levels and a decrease in the level of leukocytes in the blood.
Comparison of side effects of Ranitidine and De-nol
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Ranitidine has almost the same level of adverse events as De-nol. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Ranitidine are similar to De-nol: how quickly the body recovers after taking it and whether it recovers at all.
Brief information about Omeprazole
Omeprazole belongs to a group of antiulcer drugs that reduce the secretion of hydrochloric acid. The effect of the drug begins approximately an hour after administration, reaches maximum effectiveness after another hour, and secretion is finally restored twenty-four hours after a single dose.
Indications for use of the drug are the following diseases:
- peptic ulcer of the stomach and duodenum;
- reflux esophagitis;
- erosions and ulcerative processes in the stomach and duodenum caused by taking medications;
- ulcers caused by stress;
- Zollinger-Ellison syndrome.
The list of contraindications for taking Omeprazole is not too wide. It should not be taken if you are allergic to one of the components of the drug, young children, pregnant or lactating women.
According to the manufacturer, side effects are quite rare; in some cases, a reaction from the following may occur:
- Digestive system: stool disorders, vomiting, stomatitis, liver dysfunction (against the background of previous hepatitis).
- Nervous system: headache, dizziness, depression
- Musculoskeletal system: muscle weakness, myalgia, arthralgia.
- Circulatory systems: leukopenia, thrombocytopenia.
- Skin: itching. Allergic reactions, including anaphylactic shock, are possible.
Comparison of ease of use of Ranitidine and De-nol
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Ranitidine is approximately the same as De-nol. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2019-09-19 06:00:55
Features of admission and cancellation
If Ranitidine is taken for a long time, then if it is abruptly discontinued, “rebound” syndrome is possible.
Ranitidine for pancreatitis is taken daily, so with long-term treatment, the medicinal components accumulate in the body. The dose of Ranitidine after the course of treatment is reduced gradually.
Hydrochloric acid begins to be produced in greater quantities than before treatment with the drug. Therefore, before prescribing a medicine, the doctor gives detailed instructions on how to take and stop taking it. In acute pancreatitis, treatment is carried out according to the following scheme:
- First day: the drug is prescribed intramuscularly. The dosage is 50 mg. Injections are made 3 times a day, adding saline solution (sodium chloride) to 2 ml of the medicine to a volume of 10 ml.
- Second day: take a 150 mg tablet of Ranitidine every 12 hours.
Treatment variations are possible:
- Infusion of the solution through a dropper - 1 ampoule of Ranitidine is diluted with saline to 200 ml and administered over 2 hours.
- Take 300 mg of Ranitidine tablets at night - 1 time per day.
The maximum permissible daily dose of Ranitidine is 600 mg. If it is exceeded, the patient's condition quickly worsens: dizziness, confusion, nausea, tremors of the limbs appear - up to loss of consciousness. After complete dissolution, part of the drug leaves the body through the excretory system.
