Modern man experiences a huge negative impact of environmental factors. They have a particularly destructive effect on the organs of the gastrointestinal tract. Analysis of statistical data showed that about 15% of the adult population of the planet suffer from gastric ulcer.
The main cause of the development of ulcers and other diseases of the digestive system is a violation of the secretory activity of the stomach. As a result, the acidity of gastric juice increases, and the mucous membranes of the organs are destroyed under its influence.
To help the body cope with such pressure of hydrochloric acid, there are antisecretory agents. The most popular proton pump inhibitor drugs are Losec and Omeprazole.
Is there a difference in the prescriptions for these medications? What effect do they have on the human body? Which remedy has more contraindications? Is there a difference in price between Omeprazole and Losec?
Comparison of the effectiveness of Losec Maps and Omeprazole
The effectiveness of Losek Mapsa is quite similar to Omeprazole - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Losec Mapsa is more pronounced, then using Omeprazole even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Losec maps and Omeprazole. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Omeprazole: indications and effects on the body
Omeprazole belongs to the pharmacological group of antisecretory drugs. There are three forms of release. Coated tablets (10, 20, 40 mg). Enteric capsules (10, 20 mg) 7 capsules in a bottle. Powder in vials (40 mg), which is used for the preparation of infusion solutions. Producing countries: Russia, Spain, Belarus. The price of the drug ranges from 27 rubles. for a package of 30 capsules of 20 mg up to 107 rubles. for 14 bottles of 20 mg powder. The drug is sold in pharmacies only with a doctor's prescription.
Omeprazole contains the main component - omeprazole and auxiliary components - gelatin, glycerin, nipagin, nipazole, titanium dioxide and other components.
The medicine has the following indications for use:
- stomach and duodenal ulcers;
- peptic ulcer of the esophagus caused by the action of microorganisms;
- inflammation of the lower parts of the esophagus, resulting from the reflux of gastric juice into the esophagus;
- benign pancreatic tumors.
However, taking Omeprazole may be accompanied by unwanted side effects. Thus, patients receiving drug therapy with Omenprazole may experience dizziness, headache, drowsiness, and sometimes depression. Rarely, diarrhea, muscle weakness, and allergic reactions may occur.
Comparison of the safety of Losec maps and Omeprazole
The safety of a drug includes many factors.
At the same time, in Losek mapsa it is quite similar to Omeprazole. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Losec Mapsa, as well as Omeprazole, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Losek Mapsa does not have any risks when used, just like Omeprazole.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Losec maps and Omeprazole.
Omeprazole
Capsules belong to the gastrointestinal medications from the group of proton pump inhibitors (pumps) and are a budget alternative to Omez.
The drug suppresses the secretory activity of gastric mucosal cells responsible for the synthesis of hydrochloric acid, which is actively used in the treatment of gastroenterological pathologies:
- Zollinger-Ellison syndrome;
- erosions;
- overt illness, including associated with the bacterium Helicobacter pylori;
- gastroreflux-esophagitis disease;
- gastropathy that developed after taking medications.
Limitations for the use of proton pump inhibitor:
- breast-feeding;
- pregnancy;
- childhood and adolescence;
- liver diseases accompanied by severe impairment of its functions;
- intolerance to components.
The dosage regimen and duration of use are determined by the diagnosis and condition of the patient. The average duration of taking the medication is 1-2 months.
For patients with erosive and ulcerative disease caused by the activity of Helicobacter pylori, the drug is prescribed in combination therapy together with antibacterial agents for 7-10 days.
The most common side effects while taking the drug:
- Pain of various localizations (muscle, joint, headache, abdominal);
- Unstable psycho-emotional state;
- Symptoms of dyspepsia (increased gas production, pain and discomfort, impaired taste, loose stools, constipation);
- Allergic reactions.
Long-term treatment negatively affects calcium metabolism and provokes the development of osteoporosis.
Comparison of addiction between Losec Maps and Omeprazole
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
Thus, the totality of the values of such parameters as “o syndrome” in Losek maps is quite similar to the similar values in Omeprazole. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Losek Mapsa has a fairly low value of the “syndrome”, however, the same as for Omeprazole.
Losek: briefly about the drug
The antisecretory drug Losek is available in the form of enteric capsules, coated tablets and powder for infusion solution. Country of origin: Sweden. The price of a package of 14 tablets of 20 mg Losek is 216-747 rubles, which is significantly higher than the cost of a similar pack of Omeprazole tablets.
The basis of this drug is the biologically active substance omeprazole magnesium. Losek also contains cellulose, hypromellose, crospovidone, steril sodium furomate and other components.
Losek is prescribed for the treatment of stomach ulcers and inflammation of the esophagus, dispersion caused by high acidity.
Due to the fact that the inhibitor drug reduces the production of hydrochloric acid and inhibits the activity of enzymes in the parietal cells of the stomach. The drug is a prodrug and is activated in the acidic environment of secretory tubules.
Reasons for not taking this medication may include:
- hypersensitivity of the body to omeprazole and auxiliary components of the drug;
- lack of sucrose in the body;
- fructose intolerance.
It must be remembered that drugs containing omeprozole can mask the symptoms of malignant tumors.
Comparison of side effects of Losec Maps and Omeprazole
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Losek Mapsa has almost the same adverse events as Omeprazole. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Losek mapsa are similar to Omeprazole: how quickly the body recovers after taking it and whether it recovers at all.
Brief information about Omez
The medicine belongs to the category of medications that reduce excessive secretion of the gastric glands, responsible for maintaining the physiological pH level of the environment and the synthesis of hydrochloric acid.
Inhibition occurs as a result of an effect on the enzyme system - the proton pump.
Several dosage forms are available:
- soluble powder for oral administration;
- capsules;
- ampoules for injections.
Once in the stomach, Omez, under the influence of an acidic environment, is activated and blocks an enzyme called the “proton pump” (or pump). Due to this, the production of hydrochloric acid decreases, and, as a result, the acidity level returns to normal.
The traumatic effect of an aggressive internal environment on the condition of the mucous membrane of the digestive tract is reduced. Erosions and ulcers heal faster, and the likelihood of internal bleeding is reduced.
The medication inhibits the activity of Helicobacter pylori bacteria and increases the effectiveness of anti-Helicobacter therapy using antibiotics.
The indicated pharmacological properties have a positive effect on the health of the digestive organs in patients diagnosed with:
- gastritis;
- erosion;
- ulcer of the duodenum and stomach;
- gastropathy caused by taking gastrotoxic medications - analgesics, hormones;
- systemic mastocytosis;
- reflux esophagitis disease;
- polyendocrine adenomatosis.
Used as a prophylactic:
- in surgical practice (to avoid postoperative complications - aspiration pneumonitis);
- when taking NSAIDs.
It can be used in pediatric practice for patients weighing more than 20 kg in the treatment of reflux and peptic ulcer disease combined with Helicobacter pylori infection.
If prescribed by a doctor, it can be used in nursing women and expectant mothers. If you are intolerant to any ingredient, you should not take the medicine.
The frequency of use depends on the established diagnosis and dosage and averages 1-2 times a day.
The duration of therapy is determined individually:
- with an irradiation treatment regimen – 7-10 days;
- as an independent remedy - at least 1 month;
- in surgery it is taken once.
For pathologies of the liver and kidneys, no dose adjustment is required.
The most common side effects are dyspeptic symptoms (discomfort and abdominal pain, stool problems, nausea). With prolonged use, it worsens mineral metabolism and can provoke the appearance of osteoporosis.
Comparison of the ease of use of Losek Mapsa and Omeprazole
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Losek Mapsa is approximately the same as Omeprazole. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2019-09-19 06:00:55
What is the difference between Nolpaza and Controloc?
If the synthesis of enzymes and hormones is impaired, gastrointestinal disease can occur. When it is necessary to reduce the acidic environment in the stomach or cure ulcers and inflammation, antiulcer drugs should be taken. These products include Nolpaza and Controloc. Which drug will best cope with the problem? Research into the properties and uses of drugs will help.
Control
The active ingredient of Controloc is pantoprazole, which has a positive effect on the intestinal and gastric mucosa, slowing down the formation of aggressive hydrochloric acid, helping the production of gastrin.
Gastrin is necessary for normal digestion; when treated with Controloc, its indicator reaches the desired value, and the level of gastric juice also stabilizes. Rapid absorption makes the product bioavailable.
The medicine is used to treat the following diseases:
- mild gastroesophageal reflux disease. Its symptoms are sour belching, heartburn, nausea. A medicine is prescribed with a dose of 20 mg;
- peptic ulcer of the duodenum and stomach during exacerbation and during;
- erosive gastritis;
- destruction of Helicobacter pylori bacteria by a combination of two antibiotics;
- Zollinger-Ellison syndrome.
Nolpaza
Nolpaza is more popular. This is a drug with pantoprazole, which completely blocks the production of hydrochloric acid at the final stage, reducing stomach acidity. Nolpase capsules dissolve more slowly in the intestines due to the protective components contained in the shell. The product is considered safe for the body.
The main diseases for which doctors prescribe medication:
- stomach and duodenal ulcers, preventive and therapeutic course;
- erosive gastritis;
- eradication of Helicobacter pylori in combination with antibiotic drugs;
- Zollinger-Ellison syndrome and other pathological conditions caused by increased gastric secretions;
- erosive and ulcerative reflux esophagitis;
- gastroesophageal reflux disease (GERD);
- treatment of ulcers with complications (perforation, bleeding).
Similarities of drugs
- Both products have the same active substance - pantoprazole. Its quantity is 20 mg per tablet and 40 mg.
- Both medications are intended to treat ulcers and have the same pharmacological effects. They are proton pump inhibitors and act like a pump.
- Medicines normalize the production of digestive enzymes.
In case of urgent need, they can be used during pregnancy and lactation under the strict supervision of a doctor. - The course of treatment is prescribed by the doctor. Feedback from patients and studies have shown that the body tolerates each of the medications positively; there are adverse reactions, but in a small number of cases.
- Metabolites of drugs do not accumulate in the body, but are excreted from it along with urine and bile. Thanks to medical treatment with drugs, the damaged mucous membrane of the digestive tract is restored.
- Both drugs should not be taken in combination with alcoholic beverages.
- If the patient has renal failure, it is allowed to take pantoprazole no more than 40 mg per day. This also applies to older people.
- In case of liver dysfunction, treatment can be carried out by monitoring the quantitative content of liver enzymes.
If activity is observed, medication should be stopped. In case of severe liver dysfunction, the dose of the medicine should be no more than 20 milligrams. - Patients under the age of 18 are not recommended to take these medications.
Differences
- To prevent peptic ulcers, you can take Nolpaza. It is not recommended to take Controloc for preventive purposes.
- Controloc tablets are more effective in treating gastric reflux, which is why doctors recommend it.
- Nolpaza is considered a combination drug.
Thanks to the protective shell of the tablet, it passes through the stomach without the harmful effects of hydrochloric acid, and after four hours the concentration of the active substance in the blood plasma occurs. - Controloc is classified as a single drug without a protective shell that can withstand the effects of gastric juice. It begins to dissolve in the stomach.
- Controloc is produced in Germany, Nolpaza in Slovenia. The cost of the first drug is approximately three times higher.
Side effects
The side effects of both drugs are identical and are very rare.
The central nervous system may react with headache and dizziness. When taking Controloc, dysgeusia may rarely occur - a disorder of taste or its complete absence.
When taking both drugs, the circulatory system may become sick:
- thrombocytopenia - a decrease in platelets in plasma;
- leukopenia – a decrease in the number of leukocytes, the disease is considered oncological.
Additionally, the control can cause:
- agranulocytosis - a decrease in leukocytes and monocytes, leading to an increased risk of fungal diseases;
- Pancytopenia is a lack of all blood cells, which causes problems with the hematopoietic, immune, and lymphatic systems.
With all blood diseases, complex changes are observed in the body at the genetic level.
Medicines affect the bones and muscles of the body with the manifestation of arthralgia, myalgia.
The immune system may experience hypersensitivity, anaphylactic reactions, and anaphylactic shock.
Vision may be impaired (foggy and blurred).
The gastrointestinal tract gives the following reactions to medications:
- nausea, sometimes vomiting;
- diarrhea or constipation;
- flatulence;
- abdominal pain;
- dry mouth.
- If you examine the liver and biliary tract, you will find increased activity of liver enzymes, jaundice and hepatocellular damage.
- Mental disorders may manifest themselves slightly as depression, disorientation, and restless sleep.
- In rare cases, metabolism may be disrupted, causing a change in the patient's body weight with the development of anorexia.
- The skin may become covered with a rash, redness, and blisters (Stevens-Johnson syndrome).
- General disorders include malaise and weakness, increased body temperature.
special instructions
- For bacterial infections of the gastrointestinal tract, medications can increase the number of bacteria in the upper respiratory tract. Treatment may have a slight effect on the occurrence of intestinal infectious diseases caused by Salmonella and Campylobacter bacteria.
- You cannot take drugs with atazanavir at the same time.
- Sick patients should be constantly monitored by the attending physician if the medication is prescribed for a long time (a year or more).
- Vehicle drivers should limit their driving.
Both medications may cause dizziness and slight blurred vision. - Patients with Zollinger-Ellison syndrome should take antiulcer medications with caution.
A deficiency of vitamin B12 can occur when taking Nolpaza or Controloc, since both drugs interfere with the absorption of cyanocobalamin into the body in the required amount.
How to use
Nolpaza and Controloc should be taken in the morning, before meals. Tablets should not be crushed or chewed so that the active substance acts in the right place in the body. While taking the medicine, you need to drink plenty of fluid. You should drink plain water at room temperature. Do not drink juice, tea, coffee or other drinks.
The standard dose is one to two tablets per day. It is better to divide the double dose into morning and evening doses (before breakfast and dinner). Depending on the disease, the dosage of drugs may vary, as discussed above.
Terms of sale and shelf life
- The active substance is valid for three years. Medicines should be stored in a place away from children. Storage temperature should not exceed 25°C.
- Controloc 20-milligram tablets are available without a prescription.
- Nolpaza and Controloc 40 mg are sold only on prescription forms after a doctor’s prescription.
Which drug to take is prescribed and determined by a medical specialist. It takes into account the nature of the disease, symptoms, and severity. It is impossible to say for sure which is better: controlok or nolpaza.
For various diseases, each of the drugs is good in its own way, but both of them are aimed at treating peptic ulcers.
Source: https://omeprinfo.ru/analogi/chem-otlichaetsya-nolpaza-ot-kontroloka.html
Analogues of Omizak
Structural analogues are:
- Zerocide;
- Losek;
- Romesek;
- Omeprazole;
- Omezol;
- Ultop;
- Omez;
- Helicide.
Patients are often interested in the question: what is the difference between Omizak and Omez, are these drugs interchangeable? The active ingredient in them is the same, and both drugs are generics: Omez is a generic version of Losek, and Omizac is a generic version of Omez.
Similar therapeutic effects have:
- Lanzap;
- Lansoprazole;
- Prevacid;
- Lanzoptol.
Plisov Vladimir, doctor, medical observer
11 total today
( 64 votes, average: 4.61 out of 5)
Pantaz: instructions for use and analogues
Vishnevsky ointment: indications for use, rules of use
