Features of the disease
Gastroduodenitis is a disorder of the gastrointestinal tract, in which the inflammatory process affects the duodenum and the adjacent part of the stomach.
As the disease progresses, the mucous membrane of the digestive organs becomes thinner and degenerates. Defective formations – erosions and ulcers – may appear on it. Atrophy of the mucous layer may occur. In this case, the consequences of the disease will be very severe and difficult to cure.
Gastroduodenitis can be acute or chronic. Acute disorder is manifested by severe intense pain. In the chronic form of the disease, the pain becomes dull and the course is characterized by periods of remissions and exacerbations. The chronic course of the disease can be quite long, up to 10 years. Based on the type of lesion, a focal (localized) and diffuse type of disease is distinguished, which spreads to the entire digestive organ.
Since the inflammatory process is often accompanied by disruption of the secretory gland of the stomach, gastroduodenitis can occur with a deviation in the acidic environment. It happens:
- with high acidity;
- with a low acidic environment;
- with normal secretion.
Depending on this indicator, different treatments are prescribed.
To treat gastrointestinal diseases, people successfully use Galina Savinova’s method. Read more >>>
Often, with this disease, the motility of the intestines and stomach is impaired, and dysfunction of the sphincter (the circular muscle that pushes food into the intestines) may occur. And also, in the inflammatory process, the bile ducts are involved, which is why there are disruptions in the functioning of the gallbladder.
The symptoms accompanying this disease are quite unpleasant. These include frequent pain in the abdominal area of varying intensity, nausea, vomiting, heartburn, as well as constipation, bloating and diarrhea. The general condition of the patient is weakened, he experiences dizziness, headaches, fever, etc.
In order to fully restore the functioning of the body and finally cure the disease, comprehensive treatment is necessary. For complete recovery you need:
- eliminate the causes of inflammation;
- restore the functioning of the digestive organs;
- heal the mucous membrane;
- increase the body's protective functions.
For this purpose, multi-stage treatment with different types of drugs is used.
How to treat
Based on the examination of the patient, the doctor prescribes appropriate treatment. The type of therapy depends on the severity of the disease, its stage and causes. A fairly common cause of inflammation in the human body is the bacterium Helicobacter pylori. If tests confirm its presence in the mucosa, gastroduodenitis is treated with antibiotics.
If this disorder is caused by the presence of parasites in the duodenum, antibacterial agents are prescribed. To restore normal functioning of the body, the doctor prescribes several types of medications. These include:
- drugs of the antacid group (Omez, Omeprazole, Phosphalugel, Nolpaza, Maalox, etc.);
- antibiotics (Metronidazole, Amoxicillin, Clarithromycin, Alpha Normix, etc.);
- enzymes and substances that stimulate secretory function;
- antispasmodics and painkillers (No-shpa, Drotaverine, Duspatalin, etc.);
- drugs that restore the mucous membrane (De-nol, Sucralfate);
- medications that neutralize the effect of bile acid on the digestive tract (Ursosan, etc.);
- restoratives and vitamin complexes.
De-Nol
This is another drug that helps solve the problem of gastritis. If we talk about the chemical composition, the main content of De-Nol is citric acid. It is also called bismuth salt. This substance is distinguished by the fact that it helps to achieve excellent results in the treatment of gastritis, even if it is in a very advanced form. De-Nol is produced exclusively in the form of tablets; they can only be consumed orally.
The main indications for taking De-Nol are as follows:
- ulcerative gastric disease;
- duodenal ulcer;
- irritable colon;
- acute chronic gastritis type B;
In addition to the indications, it is good to know about the contraindications in order to avoid even bigger problems. It is completely prohibited to use the medicine during pregnancy and when breastfeeding occurs. If there is renal failure, then De-Nol should also not be used, especially if the problem is acute. De-Nol is also not prescribed if gastritis has low acidity.
In order to take De-Nol correctly, you need to know that only a doctor can prescribe it. Before use, you need to take care of proper nutrition: it is better if it becomes fractional for the period of treatment. It is also not recommended to eat too hot or cold foods.
You should take it thirty minutes before you sit down at the table. You need to drink plenty of clean water, preferably filtered or spring water. As for whether it is possible to take De-Nol and Nolpaza together, doctors do not give negative answers.
Effect of drugs
Depending on whether the acidic environment is low or high, the motility of the intestines and stomach is impaired and how much the mucous membrane is affected, the doctor prescribes the type of drugs and dosage.
You cannot treat gastroduodenitis on your own, using only one type of medication. A complex effect must be applied to the body, otherwise the inflammatory process will not be cured and complications will arise.
If the causative agent of the disease is the Helicobacter bacterium, 2-3 types of antibiotics are prescribed. This could be Metronidazole, Amoxicillin, Alpha Normix, etc. These are broad-spectrum drugs that effectively destroy many types of bacteria, including Helicobacter pylori.
Treatment regimens
When treating this disease, the causative agent of which is Helicobacter, first-line medication is carried out. In this case, Omez, Nolpaza, Omeprazole or Phosphalugel can be used, in combination with Amoxicillin and Clarithromycin.
The tablets are taken for about a week, after which the doctor conducts an examination. If the bacterium is present in the body, i.e., this treatment did not produce results, second-line therapy begins. The drugs, in this case, are replaced by others.
De-nol may be prescribed in combination with antibiotics such as Metronidazole, Tetracycline or Alpha Normix. Alpha normix is usually used in second-line schemes if the first was unsuccessful. An approximate treatment regimen may look like this.
De-nol should be taken three times a day, Metronidazole – twice, Adfa normix – taken twice a day. The dosage is indicated by the doctor. Therapy can be carried out for two weeks until complete recovery.
Medicinal effects on the body should always be combined with diet. Dietary nutrition helps to quickly restore the gastric mucosa, which affects the functioning of the entire body. This factor cannot be neglected, otherwise the treatment may be delayed.
When treating gastroduodenitis, remember that it should only be carried out comprehensively, using all measures. Don't neglect your diet and nutrition. Follow all doctor's recommendations for a speedy recovery.
Drugs for reflux esophagitis
Reflux esophagitis is a pathological process in which food is refluxed from the stomach back into the esophagus. At this time, irritation of the mucous membrane occurs.
The disease affects absolutely all people, regardless of gender or age, which is why it can be diagnosed even in children.
Therefore, it is important to know which drugs can cure this disease.
There are a huge number of reasons that influence the formation of such a disease. Among them are gastritis, adherence to an irrational diet and unhealthy lifestyle, the presence of obesity and various gastrointestinal disorders, as well as the consumption of certain specific foods.
https://www.youtube.com/watch?v=Wc2q3S36WWU
The manifestation of symptoms of such a disorder is increasing. At the initial stages of the development of the disease, they may be slightly expressed, but as they progress they become more obvious and permanent.
Signs include persistent heartburn, pain and burning in the chest area, disruption of the process of swallowing and passing food.
Treatment of the disease involves several methods, the main one of which is drug therapy.
Often, specialists use several groups of substances aimed at eliminating one or another sign of reflux esophagitis. These medications include:
- prokinetics that normalize the functioning of the lower esophageal sphincter and improve gastric and intestinal motility. One of the most common medications is Trimedat;
- Antacids – affect acidity and reduce it. The main drug of this group is Almagel, which must be taken throughout the week;
- antisecretory substances - reduce the likelihood of increased acidity. Omeprazole is isolated from this type of drug;
- antiseptic medications - the basis of such treatment is De-Nol, which has an enveloping property;
- Proton pump inhibitors (PPIs) – such drugs include Omez.
The selection of a medicinal substance depends on the type of reflux esophagitis and the nature of the disease.
In cases of diagnosing catarrhal and erosive types, antacid substances are prescribed; in the case of the formation of an abscess or phlegmon, as well as in the acute form of the disease, antibiotics are prescribed.
In addition, medications are used to normalize the motility of the stomach and intestines, as well as to reduce acid levels. The duration of taking medications and their dosage directly depends on the severity of the disease.
The basis of drug treatment is several drugs that successfully eliminate the unpleasant symptoms of reflux esophagitis. They can be produced in different forms, but often tablets are used for this illness.
One such medicinal substance is Omeprazole . It comes in the form of clear capsules and is administered orally, but if this is not possible, there is a treatment regimen using intravenous injections.
Omeprazole begins to act very quickly, within one hour - the effectiveness of taking one capsule lasts a day. The drug penetrates deep into the cells that are responsible for the production of gastric juice and enzymes, as well as the breakdown of proteins, thereby regulating these processes.
Complete restoration of hydrochloric acid production is observed five days after completion of the course of taking Omeprazole.
In addition, this medication has a bactericidal property, which makes it possible to eliminate the most common causative agent of reflux esophagitis - the bacterium Helicobacter pylori.
But it is worth considering that Omeprazole has a large number of side effects on the body, which is why it can only be used after consultation with a specialist who will prescribe the dosage and duration of treatment.
Often the duration of therapy is one month, but the course is repeated if necessary.
Another common drug used for the drug treatment of reflux esophagitis is Trimedat . It is used to eliminate this disease not only in adults, but also in children.
The main effect of this remedy is to restore normal intestinal motility, and also normalize the functioning of all parts of the digestive system. Trimedat promotes the passage of food bolus and eliminates unpleasant symptoms associated with various gastrointestinal pathologies.
In addition, the medicine eliminates tension and increased pressure in the muscles of the intestine and its lower sphincter.
Trimedat is produced only in the form of tablets intended for oral use. Despite the fact that the likelihood of side effects from this drug is quite low, you should consult a doctor before using it.
This is also due to the fact that there are several strict contraindications to taking the medicine.
These include the period of bearing a child, the occurrence of allergic reactions, individual intolerance to the drug, lactose deficiency, side effects during previous treatment with this medication.
Reflux esophagitis is accompanied by damage to the mucous membrane of the esophagus and stomach. That is why the course of drug therapy includes the drug De-Nol , which has an enveloping and antiseptic effect.
The drug is produced in the form of tablets of a specific shape - with concave surfaces on both sides. The basis of De-Nol is a substance such as bismuth, which has a beneficial effect on the mucous membrane and also protects it from acids and salts.
The main advantages of treatment with De-Nol are:
- increased mucus production, which promotes the formation of new tissue on the affected mucosa;
- De-Nol blocks the production of substances that can negatively affect the membrane;
- Compared to other drugs, it activates the movement of blood through the capillaries much more strongly.
In addition, this remedy can treat reflux esophagitis in adults and children over thirteen years of age. Some risk from using the drug De-Nol is possible with its long-term use and the accumulation of bismuth in the body.
Such a disease is best amenable to complex treatment, which is why the use of PPIs, in particular Omez, . This substance is important in reducing the secretion of gastric acidity.
Cells that produce acid increase the level of release of the hormone gastrin, which can lead to the occurrence of other gastrointestinal diseases. Thus, the use of Omez will not only eliminate the main ailment, but also prevent the occurrence of concomitant disorders.
For the treatment of reflux esophagitis, both tablet and powder forms of the drug are used. Omez has several contraindications for use, as well as side effects from prolonged use.
For this reason, before using this medicine, you should consult a specialist and strictly follow the instructions. The maximum duration of use of Omez is six months.
Along with the above drugs, the disease can also be treated with Motilium , which increases the tone of the lower esophageal sphincter, and Iberogast , which has an anti-inflammatory effect. It is also used to restore muscle tone and mucous membranes. In addition, it suppresses the proliferation of Helicobacter pylori, like Omez or Omeprazole.
In order to completely eliminate reflux esophagitis and not encounter side effects of medications, it is necessary to observe the correct dosage of the above medications, especially when treating the disease in children.
Source: https://OkGastro.ru/pishhevod/25-preparaty-pri-reflyuks-ezofagite
A little about the signs and causes of the disease
Main symptoms and their signs:
- Abdominal pain can occur regardless of food intake. Patients feel bloating in the stomach and abdomen.
- Nausea due to acute inflammation.
- Vomiting without relief.
- Belching after eating.
- Lack of appetite during exacerbations.
- Flatulence.
Why does the disease occur? The causes may be stress, poor diet, infections, and the bacterium Helicobacter pylori.
The body must produce a certain amount of gastric juice. It does not affect the mucous membrane. But when some side factors arise, the mucous membrane cannot resist the acid and becomes inflamed.
Its absorption function is impaired. The first signs of the disease appear.
special instructions
The patient's response to rabeprazole therapy does not exclude the presence of malignant neoplasms in the stomach. Khairabezol tablets should not be chewed or crushed. The tablets should be swallowed whole. It has been established that neither time of day nor food intake affects the activity of rabeprazole.
In a special study in patients with mild or moderate hepatic impairment, the incidence of side effects of rabeprazole was not found to be significantly different from that in age- and sex-matched healthy individuals, but despite this, caution is recommended when first prescribing rabeprazole to patients with severe hepatic impairment.
In patients with impaired renal or hepatic function, no dosage adjustment of Khairabezol is required. The AUC of rabeprazole in patients with severe hepatic impairment is approximately 2 times higher than in healthy patients.
Drug treatment
The gastroenterologist determines the form of the patient’s disease, associated pathologies and prescribes medications. Depending on the severity, it can be outpatient or inpatient. In acute cases, bed rest is required.
To eliminate corticovisceral disorders, adaptogens and sedatives are used.
To normalize the acid balance in the stomach, stimulants are prescribed.
Most often, doctors prescribe drugs such as De-Nol, Omez, Creon, Nolpaza, Trimedat, Omeprazole, as well as antibiotics.
Medicines are prescribed depending on the patient’s condition and medical history. They can be divided into groups:
- Antacids.
- H2 – histamine blockers.
- Proton pump inhibitors.
- Cytoprotectors.
- Prokinetics.
- Anti-Helicobacter therapy.
Antacids are taken for high acidity. They relieve pain and fight heartburn. For example, Almagel, Maalox, Simethicone. These medications are taken for two weeks during the acute period.
Histamine blockers are used for superficial gastroduodenitis. It is usually associated with increased stomach acid. For this form of the disease, Ranitidine and Famotidine are prescribed. Children over 12 years old – Famotidine 20 mg twice a day. Ranitidine - 300 mg per dose twice.
Treatment of gastroduodenitis with tablets takes a long time. You cannot suddenly stop taking medications. The dose should be reduced gradually.
For high acidity, drugs from different groups are used. Creon and Nolpaza help relieve pain at the initial stage of the disease. Prescribe diet, antibiotics and vitamins.
Patients are prescribed histamine blockers - Omez, Omeprazole. They reduce acid secretion. Nolpaza blocks the synthesis of hydrochloric acid.
For erosive gastroduodenitis, the combination drug Sucralfate is used. After taking it, a film is formed on the diseased gastric mucosa, which protects the organ from acidic contents. Duration of exposure – 6 hours.
Trimedat: analogues, similar drugs in terms of therapeutic effect
"Trimedat" is a drug that is classified as a strong antispasmodic. You can buy it at any pharmacy, the release form is tablets that are coated with a soluble coating. The product is intended to regulate the motility of the digestive tract.
When used regularly, Trimedat has an antispasmodic effect and is also able to stimulate and normalize the intestinal muscles.
The drug is prescribed for various diseases of the gastrointestinal tract that arise due to significant disturbances in the motility of the digestive organs.
In some cases, doctors prescribe analogues to patients (Creon, Duspatalin, De-Nol) based on the individual characteristics of the patient, intolerance to one or another component.
Drug analogues
Analogues of the drug "Trimedat" in terms of chemical composition are as follows:
- "Mukofalk";
- "Duspatalin";
- "Bactistatin";
- "Spakovin";
- "Creon";
- "Mukofalk."
There are analogues of Trimedat in terms of the medicinal effect of its use. Some of them:
- "Motilium";
- "Galidor";
- "Ganaton";
- "Meteospasmil";
- "No-Shpa";
- "Platifillin";
- "De-nol";
- "Papaverine";
- Dietary fiber with vitamins "Irmalax".
The release form of most of the above analogues is tablets, for example, “No-Shpa”, “Meteospasmil”, “De-Nol”, “Ganaton”, “Duspatalin”. It is not recommended to choose which of them is better; only a specialist should prescribe the drug.
Ganaton and Motilium
"Trimedat" and the drug "Ganaton" differ in the main active ingredients in each composition. The first contains trimebutine maleate, and the second contains itopride hydrochloride. Doctors prescribe Ganaton together with the drug in question to enhance the therapeutic effect.
With a joint course, the patient’s digestive process improves, and at the same time there are no complications or side effects. The drug "Ganaton" actively acts on the upper part of the digestive tract, including the inlet and outlet sections of the stomach, and the muscles of the esophagus.
“Trimedat” affects the lower part of the gastrointestinal tract: the muscles of the small intestine and large intestine.
"Ganaton" increases the motility of the digestive tract and acts as an antiemetic due to its interaction with receptors located in the trigger zone. "Ganaton" is prescribed mainly for the treatment of chronic gastritis.
Quickly relieves symptoms such as heartburn, vomiting, and frequent nausea. “Ganaton” quickly relieves the patient of pain and discomfort in the upper abdomen, relieves the feeling of fullness in the stomach, and helps with anorexia.
It is best not to replace Trimedat with the antispasmodic drug Ganaton, but to supplement treatment with it.
"Motilium" belongs to the group of antiemetics, quickly relieves symptoms such as pain, gagging, belching, heaviness in the abdomen, and frequent heartburn.
"Motilium" is prescribed if the patient is diagnosed with slowing of digestive reflux, as well as gastric emptying.
Motilium is often prescribed after or during radiotherapy or failure to adhere to a therapeutic diet, due to which a person suffers from frequent vomiting and nausea.
The drug is prescribed along with dopamine when diagnosing Parkinson's disease to avoid severe nausea and vomiting. "Motilium" can be taken by children with regurgitation syndrome, as well as cyclic vomiting.
Creon and Duspatalin
Strong enzyme preparations that replace the therapeutic effect of Trimedat include Creon, which has a beneficial effect on organs such as the pancreas and liver. "Creon" is prescribed for various disorders of the digestive system and gastrointestinal diseases. The release form is gelatin capsules, inside of which there are microspheres soluble in the intestines.
This ensures maximum effectiveness of the drug. "Creon" is strictly prohibited in cases of acute pancreatitis, in case of individual intolerance to porcine pancreatin or any of its other excipients. "Creon" can replace the drug in question only if the patient has no obvious contraindications to its use.
The drug "Creon" contains an active substance called pancreatin. There are quite a lot of drugs with this component, so it is not difficult to find analogues of the drug if there is a problem of individual intolerance to the main component.
Unlike Creon, Duspatalin is similar in its therapeutic effect on the body to Trimedat. The main difference is that the latter drug is suitable for the treatment of complex diseases of the digestive tract, while Duspatalin may not be able to cope with them. Release form: tablets.
It is also worth considering that Trimedat is much cheaper than the drug Duspatalin. The drug can be used by children over 12 years of age if pain occurs in the gastrointestinal tract.
Duspatalin is prescribed for acute pancreatitis (as opposed to Creon), for spasms or colic.
De-Nol
An effective drug for the treatment of diseases of the digestive tract is “De-Nol”, which helps restore the gastric mucosa after damage by acid produced by the human body.
"De-Nol" also enhances the protective functions of the epithelium of the lining of the main digestive organ.
A distinctive feature of the product called “De-Nol” is its excellent antimicrobial effect aimed at Helicobacter pylori, an activator of gastritis and ulcers.
Unlike Duspatalin, De-Nol is considered a strong pharmaceutical drug that can fight complex diseases. "De-Nol" is prescribed for bleeding from the rectum, for acute pain, and for the prevention of exacerbations. In general, experts most often choose the following analogues in Trimedat tablets:
- "Duspatalin";
- "Omez";
- "Nolpaza";
- "De-Nol."
All elements from the list are assigned individually to each person, depending on the diagnosis, symptoms and test data.
Meteospasmil
Combined substitutes for the medicine in question include Meteospasmil, which acts as an antispasmodic and a drug that reduces the formation of gases in the intestines. The action of Meteospasmil is based on the effect on nerve fibers, suppressing the excessive activity of enzymes that affect the tone of smooth muscles.
Recommended for diarrhea, nausea associated with digestive system disorders. In addition, the medication is effective for constipation, acute and sharp pain in the abdominal cavity, especially in the intestines. Use for diarrhea is best started at the initial stages of manifestations of the deviation, since lack of treatment can lead to severe dehydration.
Source: https://gladstomach.ru/lekarstva/analogi-trimedat.html
